Nearly impossible as an oral supplement……
What Is Curcumin?
“Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemo-preventive and chemotherapeutic activity. Curcumin is remarkably non-toxic and exhibits great promise as a therapeutic agent”, BUT IT HAS SERIOUS ISSUES WHEN TAKEN ORALLY, WHICH LIMIT ITS CLINICAL USEFULNESS. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686230/
Until now….
Read on for important information about curcumin, and by the end you will see why Zetpil™ is offering you a unique and effective solution so you CAN capitalize on the power of curcumin for improved health.
Are Curcumin and Tumeric the same thing?
It is imperative that the patient population understand that curcumin and turmeric are not the same thing.
Curcumin (curcuma longa) is the most active part of turmeric, but only represents 2-9% of turmeric makeup. One cannot assume that because they use turmeric as a dietary spice that they are ingesting any substantial amount of curcumin.
As curcumin itself is less than 1% orally bioavailable, then consuming turmeric does not supply therapeutic dosages of curcumin capable of addressing chronic health conditions. Simply put, it is a gross exaggeration to inform people that eating turmeric or taking oral curcumin will afford them the purported benefits of curcumin.
| COMPOSITION OF TUMERIC: | % |
| Curcumin (curcuminoids) | 2-6% |
| Volatile (essential) oils | 3-7% |
| Fiber | 2-7% |
| Mineral matter | 3-7% |
| Protein | 6-8% |
| Fat | 5-10% |
| Moisture | 6-13% |
| Carbohydrates | 60-70% |
Is Curcumin a “new” Phytomedicine?
No. Curcumin has been used for more than 2,000 years in Eastern medicine but it has only recently become popular in Western cultures, in large part due to the recent research that has highlighted its therapeutic potential in many chronic diseases.
What is the PROBLEM with oral Curcumin? How much Curcumin do I need?
We are going to rely on the words of scientists and researchers for the bulk of the following sections. We do not offer our opinions, but rather base our discussions on research and science, and hopefully present a cohesive picture and viable alternatives to current curcumin supplements so YOU can be empowered to make the best decision for your healthcare needs. As always, the information here is not intended as medical advice and we urge you to consult a practicing healthcare provider concerning all healthcare decisions.
PROBLEM: Despite the plethora of oral curcumin supplements on the market today, regardless of dosage, source or purity, it is nearly impossible to achieve the research-proven dosages required for curcumin to act as a potent anti-inflammatory, cancer preventative, heart disease protective compound when taken orally. The science and research indicate one must absorb approximately 30-40mg/kg/day of body weight to achieve the predictable therapeutic benefits of curcumin. http://www.ncbi.nlm.nih.gov/pubmed/19496751 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093025/pdf/nihms290140.pdf
“Despite its efficacy and safety, the clinical usefulness of curcumin is diminished by its poor oral absorption and extensive hepatic first pass metabolism, resulting in low oral bioavailability
(< 1%). Several studies suggest that oral consumption may not furnish adequate tissue levels of curcumin necessary for effective cancer prevention and treatment.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880212/?tool=pubmed
“For curcumin to exhibit any detectable levels (not therapeutic, only detectable) in the human body, a person is required to swallow between 12 and 20 g(12,000-20,000mgs) of curcumin every day; otherwise, it is unlikely that substantial concentrations of curcumin occur in the body after ingestion”.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942082/?tool=pmcentrez
“Preclinical data from phase I clinical studies have demonstrated low systemic bioavailability following oral dosing. There appears to be negligible (very little) distribution of the parent drug (curcumin itself) to hepatic (liver) tissue or other tissues beyond the gastrointestinal tract.” http://www.ncbi.nlm.nih.gov/pubmed/17569224
“Oral curcumin administration may not effectively deliver curcumin to tissues outside the gastrointestinal tract”, which eliminates its therapeutic efficacy for most types of cancer as well as other chronic conditions.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409622/pdf/90-6601623a.pdf
“Until recently, extremely high doses of curcumin were required to obtain desired blood levels. Most consumers may not realize many research studies achieved effective blood levels of curcumin by intravenous injections–directly into the veins.” These levels CANNOT be approximated with oral delivery. http://curcumin-turmeric.net/
Attempts to avoid rapid metabolism after oral ingestion of curcumin, until now, have been met with limited success. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788358/ However, the Zetpil™ Curcumin suppository may be an opportunity to potentially meet those pharmacologic levels. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084451/pdf/nihms-290167.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246621/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/?report=printable
The PROBLEM, restated…
An objective examination of all the scientific evidence proves beyond a doubt that curcumin cannot exert its full potential when taken as an oral supplement.
Most commercially available curcumin products are, on average, 400mg. If the bioavailability is 1%, then at best you are achieving only 4mg per capsule. You would need to take 12g (12,000mgs) orally for it to even just be DETECTABLE in your bloodstream. Therefore, for only a detectable dose, that would require a person to consume 30 of those 400mg pills every day and you would still never reach therapeutic dosages.
One popular online company is selling 60, 400 mg curcumin capsules for $38.00. You would need to buy 3.5 bottles every week, which totals $133.00/week and $532.00/month for this one supplement. Those 30 pills (costing $532.00/month) are also <1% absorbed so you are swallowing all those pills and you will NEVER be able to achieve therapeutic dosages.
Imagine this: On a trip to the grocery store, try to pay for $400.00 worth of groceries with $4.00. It won’t happen! The same is true when you give your body 400mg oral curcumin, <1% absorbable, and expect it to exert its powerful health-promoting benefits.
So, what’s the SOLUTION?
The solution is Zetpil™. Rather than altering the compound itself, Zetpil™ has instead altered the mode of delivery and used nanotechnological advances to increase the absorption and bioavailability of curcumin. Ultimately, Zetpil™ has been able to offer products of natural compounds which have the potential to mirror the benefits shown in the research. . http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084451/pdf/nihms-290167.pdf , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246621/
What are Curcumin’s Benefits?
Curcumin has many benefits which are health-promoting, disease preventative, as well as additive with traditional pharmaceuticals for chronic health conditions. Below is only a sampling of some of its effect on aggressive, chronic conditions.
ANTI-INFLAMMATORY CONDITIONS:
Curcumin is a potent antioxidant, clinically shown to be at least 10 times more powerful than classical antioxidants. Curcumin has been shown to possess anti-rheumatic and anti-arthritic effects, as well as efficacy with inflammatory bowel disease (IBS), pancreatitis, and other inflammatory-based health conditions. Curcumin inhibits many inflammatory markers and signaling pathways implicated in pro-inflammatory conditions. http://www.ncbi.nlm.nih.gov/pubmed/16387689 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/
Curcumin and Inflammation at PubMedCentral: more than 6,700 articles:
http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin+and+inflammation
NEURODEGENERATIVE DISEASES:
Curcumin may be useful for the prevention and treatment of neurodegenerative diseases. Curcumin has been clinically shown to suppress oxidative damage and inflammation, decrease cognitive deficits and reverse the amyloid pathology associated with Alzheimer’s and other age-related pathologies. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876259/ http://www.ncbi.nlm.nih.gov/pubmed/16387689 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744901/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578106/ http://www.ncbi.nlm.nih.gov/pubmed/22742420
Curcumin and Neurodegenerative Diseases at PubMedCentral: more than 2,100 articles http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin%20and%20neurodegenerative%20diseases
CARDIOVASCULAR DISEASE:
Some research suggests that curcumin may be helpful in reducing cardiac inflammation, as well as reduce total cholesterol level and LDL cholesterol levels in acute coronary patients. Curcumin has shown effectiveness against atherosclerosis and myocardial infarction (heart attacks). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535097/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820045/
Curcumin and Cardiovascular Disease at PubMedCentral: more than 3,300 articles:
http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin+and+cardiovascular+disease
DIABETES:
Curcumin may help prevent the onset of diabetes in those with the greatest risk factors (ie: obesity). Curcumin may be beneficial in diabetes and obesity by reversing insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857752/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476912/
Curcumin and Diabetes at PubMedCentral: more than 3,400 articles:
http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin+and+diabetes
CANCER:
Research suggests that curcumin may be able to reduce the side effects of chemotherapy, be a potent free radical scavenger as well as reduce cancer-related inflammatory markers. Curcumin has been shown to block tumor initiation, promotion, invasion and metastasis in many different tumors. “Although identified as a potent anticancer agent, clinical studies have shown mixed results because of its hydrophobicity, low gastrointestinal absorption, poor bioavailability and rapid metabolism.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312397/
Curcumin and Cancer at PubMedCentral: more than 9,700 articles:
http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin+and+cancer
References
There are almost 9,000 free peer-reviewed scholarly articles about curcumin at the U.S. National Library of Medicine (www.ncbi.com). We encourage anyone looking for scientific and medical information to follow this link. http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin
Discovery of Curcumin, a Component of the Golden Spice, and Its Miraculous Biological Activities
Clin Exp Pharmacol Physiol Mar 2012; 39(3): 283–299
Subash C Gupta, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288651/
Plant derived substances with anti-cancer activity: from folklore to practice
Marcelo Fridlender, et al
Front Plant Sci 2015 Oct 1; 6:799
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589652/
Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice
Prasad S, et al
Cancer Res Treat 2014 Jan; 46(1):2-18
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/
Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health
Ali Mobasheri, et al
Int. J. Mol. Sci. 2012, 13, 4202-4232
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/’
Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century
Wing-Hin Lee, et al
Current Neuropharmacology, 2013, 11, 338-378
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744901/
Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc™) blocks tumor growth and metastases in preclinical models of pancreatic cancer
Savita Bisht, et al
Mol Cancer Ther 2010 August; 9(8): 2255–2264
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942082/?tool=pmcentrez
Curcumin nanoparticles: preparation, characterization, and antimicrobial study
Bhawana, Basniwal RK, Buttar HS, Jain VK, Jain N
J Agric Food Chem, 2011 Mar 9; 59(5):2056-61
http://www.ncbi.nlm.nih.gov/pubmed/21322563
Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway
Jong-Rung Tsai, et al
PLoS ONE 10(12): e0144462
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144462
Inhibitory effects and molecular mechanisms of tetrahydrocurcumin against human breast cancer MCF-7 cells
Xiao Han, et al
Food Nutr Res 2016 Feb 17; 60:30616
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761686/
Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention
Shahani K, et al
Cancer Res 2010 Jun 1; 70(11):4443-52
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880212/?tool=pubmed
Potential Applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy
Mimeault M, Batra SK
Chinese Medicine 2011; 6:31
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177878/pdf/1749-8546-6-31.pdf
Perspectives on Chemopreventive and Therapeutic Potential of Curcumin Analogs in Medicinal Chemistry
Padhye, et al
Mini Rev Med Chem 2010; 10(5): 372–387
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084451/pdf/nihms-290167.pdf
Targets of Curcumin
Hongyu Zhou, et al
Curr Drug Targets 2011; March 1; 12(3): 332–347
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025067/pdf/nihms-201350.pdf
Phytochemicals as Chemosensitizers: From Molecular Mechanism to Clinical Significance
Vinod BS, Maliekal TT, Anto RJ.
Antioxid Redox Signal 2012 Aug 7
http://www.ncbi.nlm.nih.gov/pubmed/22871022
Why Pleiotropic Interventions are Needed for Alzheimer’s Disease
Mol Neurobiol Jun 2010; 41(2-3): 392–409
Sally A. Frautschy, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876259/
Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century
Curr Neuropharmacol Jul 2013; 11(4): 338–378
Wing-Hin Lee, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744901/
Mucoadhesive drug delivery systems
Rahamatullah Shaikh, et al
J Pharm Bioallied Sci 2011 Jan-Mar; 3(1): 89–100
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/?report=printable
Mucoadhesive drug delivery system: An overview
Bindu M. Boddupalli, et al
J Adv Pharm Technol Res. 2010 Oct-Dec; 1(4): 381–387
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/?report=printable
Docetaxel-Loaded Thermosensitive and Bioadhesive Nanomicelles as a Rectal Drug Delivery System for Enhanced Chemotherapeutic Effect
Seo YG, et al
Pharm Res. 2013 Apr 3
http://www.ncbi.nlm.nih.gov/pubmed/23549753
Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention
Adriana Albini, et al
J Natl Cancer Inst. 2010 January 6; 102(1): 14–25
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802286/?report=abstract&tool=pmcentrez
