Zetpil™ 98 % Trans-RESVERATROL Suppository

What is Reservatrol?

Resveratrol (3,5,4′-trihydroxystilbene), harvested from the roots of Polygonum Cupsidatum, is a polyphenol found in various berries, nuts, and other plant sources. Resveratrol is a phytoalexin (anti-microbial and antioxidative compound), synthesizedby plants during environmental stress and pathogenic invasion, thereby acting as a natural inhibitor of cell proliferation.

Revered for its health benefits since ancient times, Resveratrol began its more recent rise to fame in the 1990s with the coining of the “French Paradox”, the observation that French people have low risk of coronary artery disease despite consuming red wine along with a high fat diet.  ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348475/} 

Resveratrol is primarily available in its trans– form because this is the form most studied and recognized for powerful antioxidant properties, including its ability to influence a variety of “oxidative stress-associated diseases”. ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713511/}  Resveratrol has shown to be effective for:

• Immune function,
• Longevity (anti-aging),
• Heart disease,
• Neurologic disorders,
• Metabolic disorders, and
• Degenerative conditions.

^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713511/}

Resveratrol’s Therapeutic Properties

ANTI-AGING: The potential of trans-Resveratrol for anti-aging has been linked to its ability to activate the Sirt1 gene, which is linked to cellular life-span extension. Resveratrol’s antioxidant actions have been shown to decrease mitochondrial production of reactive oxygen species (ROS), which is important because mitochondrial dysfunction and excessive ROS (leading to oxidative damage) lies at the heart of the aging process.

CARDIOVASCULAR HEALTH: Resveratrol has been shown to have strong antioxidant properties and can inhibit platelet aggregation (blood thinning property), a known risk factor for heart attacks and strokes.

CANCER: Resveratrol possesses strong anti-proliferative properties and may act to induce apoptosis (cell death) in many cancer cell lines as well as decrease treatment-induced side effects and enhance current anti-cancer therapies.

NEUROLOGIC CONDITIONS: Resveratrol has neuro-protectant properties and may help protect nerve cells from damage as well as inhibit the buildup of plague that can lead to Alzheimer’s and other neurodegenerative diseases (i.e. Parkinson’s, multiple sclerosis).

DIABETES: Scientific evidence has shown that resveratrol induces favorable changes in diabetic patients.  Resveratrol may be able to induce changes in gene expressions, enzyme activities, decrease cytokine action (pro-inflammatory responses) as well as possibly reduce the pancreatic oxidative damage caused by diabetes.

http://www.ncbi.nlm.nih.gov/pubmed/22822401

Supplement Facts

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

Due to the nature of the product suppositories cannot be returned or exchanged.

WARNINGS:

• Although safe for children, this product should be kept out of the reach of children.
• Do not use if the suppositories are open or damaged.
• As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
• This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.        

References

There are more than 9,600 free peer-reviewed scholarly articles about resveratrol at the U.S. National Library of Medicine (www.ncbi.com).  We encourage anyone looking for scientific and medical information to follow this link.http://www.ncbi.nlm.nih.gov/pmc/?term=resveratrol

Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 1

S.M. Sagar, MD, et al

Curr Oncol. 2006 February; 13(1): 14–26

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891166/pdf/CO13_1p014.pdf

Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 2

S.M. Sagar, MD, D. Yance, MH, and R.K. Wong, MD

Curr Oncol 2006 June; 13(3): 99–107

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891180/pdf/CO13_3p099.pdf

The journey of resveratrol from yeast to human

Aging (Albany NY) Mar 2012; 4(3): 146–158

Silvie Timmers, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348475/

Resveratrol-based combinatorial strategies for cancer management

Ann N Y Acad Sci Jul 2013; 1290(1): 113–121

Chandra K. Singh

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713511/

Resveratrol: Biological and pharmaceutical properties as anticancer molecule

Biofactors 2010 Sep-Oct; 36(5): 360–369

Tze-chen Hsieh

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655417/

Dose-Dependency of Resveratrol in Providing Health Benefits

Subhendu Mukherjee, Jocelyn I. Dudley, Dipak K. Das

Dose Response2010; 8(4): 478–500

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990065/pdf/drp-08-478.pdf

Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention

Mohammad Athar

Toxicol Appl Pharmacol. 2007 November 1; 224(3): 274–283

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083123/

Transport, stability, and biological activity of resveratrol

Delmas D, et al

Ann N Y Acad Sci. 2011 Jan; 1215:48-59.

http://www.ncbi.nlm.nih.gov/pubmed/21261641

Resveratrol: challenges in translation to the clinic – A critical discussion

Lalita Subramanian, et al.

Clinical Cancer Research, 2010

http://clincancerres.aacrjournals.org/content/early/2010/10/29/1078-0432.CCR-10-1486

Therapeutic potential of resveratrol: the in vivo evidence

Joseph A. Baur & David A. Sinclair

Nature Reviews Drug Discovery 5, 493-506 (June 2006)

http://www.nature.com/nrd/journal/v5/n6/abs/nrd2060.html

Phytochemicals as Chemosensitizers: From Molecular Mechanism to Clinical Significance

Vinod BS, Maliekal TT, Anto RJ.

Antioxid Redox Signal 2012 Aug 7

http://www.ncbi.nlm.nih.gov/pubmed/22871022

Polyphenols and Aging

Brannon L. Queen and Trygve O. Tollefsbol

Curr Aging Sci 2010 February; 3(1): 34–42

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896035/

Neuroprotective effects of resveratrol in Alzheimer disease pathology

Front Aging Neurosci  2014; 6: 218 

Shraddha D. Rege, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161050/

Resveratrol Reverses Remodeling in Hearts with Large, Old Myocardial Infarctions through Enhanced Autophagy-Activating AMP Kinase Pathway

Kanamori H, et al

Am J Pathol 2012 Dec 27

http://www.ncbi.nlm.nih.gov/pubmed/23274061

Longevity nutrients resveratrol, wines and grapes

Istvan Lekli, et al

Genes Nutr (2010) 5:55–60

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820197/pdf/12263_2009_Article_145.pdf

Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health

Ali Mobasheri, et al

Int J Mol Sci 2012; 13(4): 4202–4232

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/pdf/ijms-13-04202.pdf

Curcuminoids and resveratrol as anti-Alzheimer agents

Villaflores OB, et al

Taiwan J Obstet Gynecol 2012 Dec; 51(4):515-25

http://www.ncbi.nlm.nih.gov/pubmed/23276553

High absorption but very low bioavailability of oral resveratrol in humans

Walle T, et al

Drug Metab Dispos 2004 Dec; 32(12):1377-82

http://dmd.aspetjournals.org/content/32/12/1377.full.pdf

Equipoise Lost: Ethics, Costs, and the Regulation of Cancer Clinical Research

David J. Stewart, et al

Journal of Clinical Oncology; VOLUME 28 _ NUMBER 17 _ JUNE 10 2010

http://jco.ascopubs.org/content/28/17/2925.full.pdf

Mucoadhesive drug delivery systems

Rahamatullah Shaikh, et al

J Pharm Bioallied Sci 2011 Jan-Mar; 3(1): 89–100

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/?report=printable

Mucoadhesive drug delivery system: An overview

Bindu M. Boddupalli, et al

J Adv Pharm Technol Res. 2010 Oct-Dec; 1(4): 381–387

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/?report=printable

Docetaxel-Loaded Thermosensitive and Bioadhesive Nanomicelles as a Rectal Drug Delivery System for Enhanced Chemotherapeutic Effect

Seo YG, et al

Pharm Res. 2013 Apr 3

http://www.ncbi.nlm.nih.gov/pubmed/23549753

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

Adriana Albini, et al

J Natl Cancer Inst. 2010 January 6; 102(1): 14–25

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802286/?report=abstract&tool=pmcentrez

Resveratrol: Anti-Obesity Mechanisms of Action

Molecules 2014 Nov 14; 19(11):18632-18655

Aguirre L, et al

http://www.mdpi.com/1420-3049/19/11/18632