Description
The Zetpil™ Branched Chain Amino Acid cream contains the essential amino acids leucine, isoleucine and valine, which must be consumed through diet since the human body cannot make them from other compounds. Branched Chain Amino Acids (BCAAs hereafter) make up 35% of the amino acids in muscle proteins and 40% of the essential amino acids required by humans. Research has shown BCAAs to be beneficial for promoting healthy muscle mass, improving overall exercise performance, decreasing fatigue post-training, providing essential nutritional support, and may be important in preventing cancer-induced cachexia.
The Zetpil “Now Factor”
Deep-penetrating creams, unlike oral supplements, allow direct application of BCAAs to your specified target site (ie: muscles in training, abdomen, etc.) thereby reaching desired areas quickly. As these nutrients are in “final form” and easily recognized by the body, they do not have to undergo any biotransformation (changes to the compound induced by the body). The “Now Factor” means quick and therapeutic utilization of these essential nutrients.
Zetpil™ Deep-penetrating, Ultra-absorbable Cream Advantage:
Zetpil™ delivers nutrition through the skin with the use of deep-penetrating, ultra-absorbable creams that have a unique, proprietary formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method. These creams are a result of combining natural ingredients with a non-irritating, rapidly absorbable, antioxidant base and delivering the nutrients directly into the bloodstream in less than 10 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.
Additionally, many raw materials simply have a very low oral bioavailability , and only achieve around 10% or less absorption rates, even if the patient is in an optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues. Zetpil™ deep penetrating creams, are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy and cost effective.
What Is The Source?
The Branched Chain Amino Acid cream is ideal for those individuals who wish to maintain a meat- free, vegetarian diet. Isoleucine and valine are produced from corn dextrose fermentation. Leucine is extracted from a variety of protein sources (primarily soybeans) and undergoes extensive processing and purification before achieving its final bioavailable form.
Research-Proven Uses for Branched Chain Amino Acids
Exercise and Training
Exercise and Training-Related Benefits
“The International Society of Sports Nutrition (ISSN) has concluded that consuming BCAAs (in addition to carbohydrates) before, during, and following an exercise bout would be recommended safe and effective”, in part for the reasons described below. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853497/
Branched Chain Amino Acids may play a role in athletic support by:
- promoting muscle nitrogen,
- enhancing alanine and glutamine production,
- decreasing lactate production,
- moderating central nervous system fatigue thereby supporting mental performance, and
- boosting energy while decreasing protein breakdown= increased muscle work capacity and recovery.
“Branched Chain Amino Acids (BCAA) conserve muscle mass and indeed, studies examining recovery from heavy endurance activity have shown evidence that BCAA are beneficial in reducing muscle damage (ie: soreness) and accelerating the recovery process.” Prior experiments “showed that amino acid supplementation was effective in reducing muscle damage and soreness when consumed immediately before and during the four recovery days that followed a damaging bout of exercise.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395580/
“Branched-chain amino acids (valine, leucine, and isoleucine; BCAAs) help to inhibit protein breakdown and enhance protein synthesis. BCAAs have been reported in many studies to attenuate delayed onset muscle soreness (DOMS) and muscle damage induced by exercise.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827986/
“It is clear that exercise promotes degradation of BCAAs and yet muscle-protein synthesis is enhanced after exercise. Therefore BCAA supplementation before and after exercise has beneficial effects for decreasing exercise-induced muscle damage and promoting muscle-protein synthesis.”
Cancer Cachexia
Cancer Cachexia
Cachexia is clinically recognized as unintentional, progressive weight loss and wasting of muscle tissue caused both by the natural course of the disease as well as a serious side effect from current medical treatments. Branched chain amino acids may be beneficial for the prevention and/or treatment of cancer-induced cachexia, a condition experienced by 50%-80% of all cancer patients and is a significant risk factor for treatment failure, toxicity and shorter survival. In fact, cachexia kills up to 25% of cancer patients regardless of diagnosis or treatment success. http://www.ncbi.nlm.nih.gov/pubmed/15213711
“Protein synthesis requires a correctly balanced mixture of amino acids, and a number of studies have noted widespread decreases in the plasma levels of free amino acids in patients with cachexia. The maximum decreases are often found for the BCAAs (branched-chain amino acids) leucine, isoleucine and valine.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267397/
“The administration of exogenous (supplemental) amino acids, specifically branched-chain amino acids, has been used with the aim of improving muscle protein metabolism”, and the combination of “amino acids had a more significant effect (on cachexia) than that of EPA alone” http://www.ncbi.nlm.nih.gov/pubmed/15213711,
Commonly Megastrol acetate (Megace) is prescribed and is used as an appetite stimulant which acts to suppress some inflammatory conditions believed to be partly responsible for this condition. Unfortunately, Megace, like other pharmaceutical options, has numerous side effects, some severe and potentially life threatening.
“Megace has not shown promise in increasing lean body mass or markers of protein metabolism in the cachectic cancer patient.”http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016925/
Liver Cirrhosis
Liver Cirrhosis
“Cirrhosis is a slowly progressing disease in which healthy liver tissue is replaced with scar tissue, eventually preventing the liver from functioning properly. The scar tissue blocks the flow of blood through the liver and slows the processing of nutrients, hormones, drugs, and naturally produced toxins. It also slows the production of proteins and other substances made by the liver.” http://www.webmd.com/digestive-disorders/cirrhosis-liver
Therefore, diseases affecting the liver (ie: Hepatitic C, fatty liver, alcohol abuse) drastically affect a person’s nutrient status. These nutrient deficiencies can cause muscle weakness, fatigue, fluid retention, jaundice and overall diminished quality of life (QOL).
Since “serum concentrations of BCAAs are decreased in patients with advanced liver diseases, several clinical trials have suggested that Branched Chain Amino Acid (BCAA) supplementation improves the prognosis of cirrhotic patients (by, but not limited to)”:
- improving protein malnutrition and nutritional status in patients;
- reducing the frequency of albumin infusion in children with end-stage liver disease;
- reducing oxidative stress by reducing iron accumulation;
- attenuating fibrosis; and
- improving glucose metabolism.
References
References
Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise
J Int Soc Sports Nutr 2013 Nov 6; 10(1):51
Ra SG, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827986/
Exercise Promotes BCAA Catabolism: Effects of BCAA Supplementation on Skeletal Muscle during Exercise
J. Nutr. June 1, 2004 vol. 134 no. 6 1583S-1587S
Yoshiharu Shimomura, et al
http://jn.nutrition.org/content/134/6/1583S.abstract
Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study
J Int Soc Sports Nutr 2012 Jul 12; 9:20
Howatson G, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395580/
ISSN exercise & sport nutrition review: research & recommendations
J Int Soc Sports Nutr 2010; 7: 7
Richard B Kreider, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853497/
Effect of branched-chain amino acids on muscle atrophy in cancer cachexia
Biochem J. Oct 1, 2007; 407(Pt 1): 113–120
Helen L. Eley, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267397/
Effect of eicosapentaenoic acid, protein and amino acids on protein synthesis and degradation in skeletal muscle of cachectic mice
Br J Cancer 2004 Jul 19;91(2):408-12
Smith HJ, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409806/
Systemic inflammation, cachexia and prognosis in patients with cancer
Curr Opin Clin Nutr Metab Care 2005 May; 8(3):265-9
Deans C, et al
http://www.ncbi.nlm.nih.gov/pubmed/15809528
Cancer Cachexia: Traditional Therapies and Novel Molecular Mechanism-Based Approaches to Treatment
Curr Treat Options Oncol Dec 2010; 11(3-4): 107–117
Nagi B. Kumar, PhD, RD, FADA, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016925/
Branched-Chain Amino Acid Supplementation Reduces Oxidative Stress and Prolongs Survival in Rats with Advanced Liver Cirrhosis
PLoS One 2013; 8(7): e70309
Motoh Iwasa, et al
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723692/
Branched-chain amino acids in liver diseases
World J Gastroenterol Nov 21, 2013; 19(43): 7620–7629
Kazuto Tajiri and Yukihiro Shimizu
