Zetpil™ Curcumin Suppository

The PROPOGANDA of Curcumin

Understanding the pharmacology of natural compounds requires some time and effort.  Research, from all over the world, spanning decades tells us the therapeutic properties of curcumin cannot be realized when taken orally.  Yet we are constantly bombarded by nutritional companies, health gurus and the media alike preaching the benefits of curcumin from a bottle.  So, what’s the truth?

• “For curcumin to exhibit any therapeutic effects in the human body, a person is required to swallow between 12 and 20 g (12,000-20,000mgs) of curcumin every day; otherwise, it is unlikely that substantial concentrations of curcumin occur in the body after ingestion”.^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942082/?tool=pmcentrez    http://www.ncbi.nlm.nih.gov/pubmed/21322563}

• “Despite its efficacy and safety, the clinical usefulness of curcumin is diminished by its poor oral absorption and extensive first pass metabolism, resulting in low oral bioavailability (< 1%). Several studies suggest that oral consumption may not furnish adequate tissue levels of curcumin necessary for effective cancer prevention and treatment. “^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880212/?tool=pubmed}

• “The highest dose of 12,000 mg/day was not acceptable to some patients because of the large amount of the curcumin capsules necessary to reach this high dose. The side effects that have been observed with curcumin given orally include mild diarrhea and nausea, headache, and rash.” ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177878/pdf/1749-8546-6-31.pdf}

Research dictates that 12g (12,000mgs) of curcumin must be taken orally for it to even just be DETECTABLE in your bloodstream, not to achieve therapeutic dosages, just for it to be detectable.  That would mean, just for a detectable dosage,  30 of those 400mg pills every day, which is not only difficult to swallow, literally, it is certainly not cost effective.   One popular online company is selling 60, 400 mg curcumin capsules for $38.00.  You would need to buy 3.5 bottles every week, which totals $133.00/week and $532.00/month for this one supplement. Those 30 pills are still also <1% absorbed.

Although many pharmaceutical companies are actively testing various oral formulations of curcumin, it is not uncommon for the process of clinical trials and product development to take more than 12 years. ^{http://jco.ascopubs.org/content/28/17/2925.full.pdf}

However, there is hope!  

What makes the Zetpil™ Curcumin Different?

Zetpil™ Curcumin is unique because it represents the marriage of science and reality.  By embracing the physical properties of curcumin (low oral bioavailability), the researchers and scientists at Zetpil™ conceived that an alternative delivery method may increase the levels of curcumin one could achieve over a longer period of time.  Based on research-proven concepts of absorption-enhancing natural compounds, excipients, therapeutically effective dosages and state-of-the-art production methods, Zetpil™ has formulated a curcumin product which is cost-effective, safe, non-competitive, avoids enzymatic breakdown in the stomach and liver and is patient-friendly.  The science indicates one must absorb approximately 30-40mg/kg/day of body weight to achieve the predictable therapeutic benefits of curcumin.  The Zetpil™ Curcumin suppository offers the health-conscious consumer the opportunity to potentially meet those levels. ^{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084451/pdf/nihms-290167.pdf , http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246621/}

Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues.

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

A Glimpse at Some of Curcumin’s Therapeutic Properties

ANTI-INFLAMMATORY CONDITIONS: May be helpful for arthritis, inflammatory bowel disease (IBS), pancreatitis, and other inflammatory-based health conditions. Curcumin inhibits many inflammatory markers, including, but not limited to the Cox-2 enzyme (Cox-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF-α), and nuclear factor kappa B (NF-κB).

NEURODEGENERATIVE DISEASES: Curcumin may be useful for the prevention and treatment of neurodegenerative diseases.  It has been clinically shown to reverse the amyloid pathology associated with Alzheimer’s and other age-related pathologies.

CARDIOVASCULAR DISEASE:  Some research suggests that curcumin may be helpful in reducing cardiac inflammation, as well as reduce total cholesterol level and LDL cholesterol levels in acute coronary patients.

DIABETES: Curcumin may be beneficial in diabetes and obesity by reversing insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.

CANCER:  Research suggests that curcumin may be able to reduce the side effects of chemotherapy, be a potent free radical scavenger as well as reduce cancer-related inflammatory markers.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637808/

Supplement Facts

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Due to the nature of the product suppositories cannot be returned or exchanged.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

WARNINGS

• Although safe for children, this product should be kept out of the reach of children.
• Do not use if the suppositories are open or damaged.
• As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice. 

References

There are almost 9,000 free peer-reviewed scholarly articles about curcumin at the U.S. National Library of Medicine (www.ncbi.com).  We encourage anyone looking for scientific and medical information to follow this link.http://www.ncbi.nlm.nih.gov/pmc/?term=curcumin

Discovery of Curcumin, a Component of the Golden Spice, and Its Miraculous Biological Activities

Clin Exp Pharmacol Physiol Mar 2012; 39(3): 283–299

Subash C Gupta, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288651/

Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc™) blocks tumor growth and metastases in preclinical models of pancreatic cancer

Savita Bisht, et al

Mol Cancer Ther 2010 August; 9(8): 2255–2264

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942082/?tool=pmcentrez

Curcumin nanoparticles: preparation, characterization, and antimicrobial study

Bhawana, Basniwal RK, Buttar HS, Jain VK, Jain N

J Agric Food Chem, 2011 Mar 9; 59(5):2056-61

http://www.ncbi.nlm.nih.gov/pubmed/21322563

Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention

Shahani K, et al

Cancer Res 2010 Jun 1; 70(11):4443-52

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880212/?tool=pubmed

Potential Applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy

Mimeault M, Batra SK

Chinese Medicine 2011; 6:31

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177878/pdf/1749-8546-6-31.pdf

Perspectives on Chemopreventive and Therapeutic Potential of Curcumin Analogs in Medicinal Chemistry

1. Padhye, et al

Mini Rev Med Chem 2010; 10(5): 372–387

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084451/pdf/nihms-290167.pdf

Targets of Curcumin

Hongyu Zhou, et al

Curr Drug Targets 2011; March 1; 12(3): 332–347

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025067/pdf/nihms-201350.pdf

Phytochemicals as Chemosensitizers: From Molecular Mechanism to Clinical Significance

Vinod BS, Maliekal TT, Anto RJ.

Antioxid Redox Signal 2012 Aug 7

http://www.ncbi.nlm.nih.gov/pubmed/22871022

Why Pleiotropic Interventions are Needed for Alzheimer’s Disease

Mol Neurobiol Jun 2010; 41(2-3): 392–409

Sally A. Frautschy, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876259/

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

Curr Neuropharmacol Jul 2013; 11(4): 338–378

Wing-Hin Lee, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744901/

Mucoadhesive drug delivery systems

Rahamatullah Shaikh, et al

J Pharm Bioallied Sci 2011 Jan-Mar; 3(1): 89–100

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053525/?report=printable

Mucoadhesive drug delivery system: An overview

Bindu M. Boddupalli, et al

J Adv Pharm Technol Res. 2010 Oct-Dec; 1(4): 381–387

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255397/?report=printable

Docetaxel-Loaded Thermosensitive and Bioadhesive Nanomicelles as a Rectal Drug Delivery System for Enhanced Chemotherapeutic Effect

Seo YG, et al

Pharm Res. 2013 Apr 3

http://www.ncbi.nlm.nih.gov/pubmed/23549753

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

Adriana Albini, et al

J Natl Cancer Inst. 2010 January 6; 102(1): 14–25

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802286/?report=abstract&tool=pmcentrez