Zetpil™ Melatonin 400mg SR Suppository

What is Melatonin?

Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine (neurotransmitter) which is synthesized not only within the pineal gland in the brain, but has also been shown to be synthesized in many other parts of the body including, but not limited to, organs, the eye, gut, bone marrow, skin and immune cells.  The role of melatonin in circadian rhythm disturbances and sleep disorders is well established.

However, in the last several years, over 4,500 publications in peer-reviewed journals in the National Library of Medicine have confirmed melatonin, at higher dosages, to be the most powerful antioxidant in existence and the only universal free radical scavenger.

Patient and professional understanding of this unique and powerful signaling molecule must extend beyond jet lag and sleep aid. Some of its multiple beneficial functions may include powerful antioxidant, DNA protectant, immune function gatekeeper, and a natural oncostatic (anti-cancer) molecule. The research conducted in these regards has unequivocally documented melatonin’s ability to detoxify ALL harmful free radicals which cause molecular damage leading to disease and dysfunction.

What makes Melatonin so Powerful?

To this end, Melatonin still supersedes even glutathione in the battle for antioxidant status because melatonin itself increases the body’s own glutathione production.  Simply put, melatonin has the ability to induce an “antioxidant avalanche” of sorts with its own unique free radical scavenging properties, its ability to increase our body’s own antioxidant defenses (ie: glutathione), and by producing metabolites which are equally as powerful to continue the battle against oxidative damage.

More importantly, the research has demonstrated unequivocally that melatonin is completely non-toxic and is safe to take with most if not all medications. This combination of effectiveness and safety makes the use of melatonin a key compound in the treatment of numerous disease states, chronic diseases, and age-related diseases in humans where free radicals are a fundamental component.

An average human being contains about 10¹⁴ cells (one hundred trillion, or 100,000,000,000,000).  Each of these cells receives tens of thousands of potential DNA insults every day.  A huge part of free radical-based disease prevention (ie: cancer, neurodegenerative and cardiovascular diseases) lies in being able to continually prevent that DNA damage.  Melatonin confers unique and unparalleled protection to those hundred trillion cells on a daily basis.

Why can’t I take a generic melatonin supplement?

Most people are convinced that low oral dosages of melatonin (2mg- 10 mg), which is enough to help moderate jet lag, can also exert the additional antioxidant benefits of melatonin.  This is simply not true. 

Not only is the oral bioavailability of melatonin <15%, but when melatonin is taken orally it must also undergo further metabolism in the liver. The liver does not release melatonin efficiently and much of this melatonin is essentially “trapped” in the liver.  So, the poor absorption rate and the difficulty in breaking down orally-ingested melatonin in the liver make it nearly impossible for individuals to achieve all of the anti-oxidative benefits of melatonin when taken orally. In fact, research has deemed melatonin to be classified by pharmacologists as a low permeability compound (ie: poor absorption) due to its low oral bioavailability. 

What about sublingual Melatonin?

Unfortunately, the vast majority of these products on the market are low dosages that are combined with a form of sugar, sometimes alcohol and preservatives. There is no scientific basis to believe these additives increase absorption in any appreciable amount capable of exerting any antioxidant activity.

Therapeutic Properties of Melatonin

• Melatonin is found in all the cells of all life forms currently known and has been for millions of years.
• Melatonin is uniquely powerful in that it can neutralize every type of free radical (ie: ROS and RNS) and prevent their formation.
• Melatonin is an antioxidant that may prevent mitochondrial dysfunction and induce cellular differentiation, both of which are precursors to aging and diseases.
• Melatonin may reverse both acute and chronic inflammation.
• Melatonin may decrease harmful nitric oxide levels.
• Melatonin does not recycle and become a free radical itself like classical antioxidants vitamin C or E.
• Melatonin increases the levels of the body’s own powerful antioxidants, like Glutathione.
• Melatonin scavenges free radicals with a 10:1 ratio (versus a 1:1 ratio for classical antioxidants). Its ability to produce powerful antioxidant metabolites accounts for this superior squelching ratio.
• Melatonin is an antioxidant that may play a role in DNA repair.

Melatonin may be beneficial for the prevention and/or treatment of the following diseases:

• Cancer
• Heart Disease
• Diabetes
• Autism
• Neurodegenerative Diseases (ie: Alzheimer’s or Parkinson’s)
• Arthritis
• Age-related vision and hearing loss

Supplement Facts

Some individuals become drowsy immediately after usage and should adjust the administration time accordingly.

Due to the nature of the product, suppositories cannot be returned or exchanged.

Note: Storing this product at room temperature will not alter the effectiveness or potency. However, a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion. Avoid excessive heat 40°C (104°F). Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate.

Warnings:

• If pregnant or lactating, consult your physician before taking this product
• Keep out of reach of children
• Do not exceed recommended dose
• Do not use if the suppositories are open or damaged
• This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA.  This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.