Zetpil™ ProstaFlow Plus Suppository

What is the Prostate?

The prostate is a gland found only in males.  It starts to develop before birth and after puberty it usually stays the same size throughout adulthood as long as male hormones are present. As post-menopausal women are more likely to get breast cancer due to the decrease in estrogen production, older males are more likely to develop prostate-related issues due to the decrease in testosterone production (“male menopause”- andropause).

The Zetpil Solution for Prostate Health

The Zetpil™ Prostaflow Plus rectal suppository is a uniquely commonsense approach which may help to address the issues leading to prostate dysfunction, such as Benign Prostatic Hypertrophy (BPN) and prostate cancer. In addition to a combination of phytonutrients at therapeutically effective dosages, these suppositories also contain absorption-enhancing ingredients that ensure the delivery of the active nutrients DIRECTLY into the bloodstream. When taken at night, the absorption levels exceed 70% of these key compounds. This is approximately 12 TIMES the amount absorbed when taken by mouth.

These prostate-beneficial compounds include Nettle root extract, Betasitosterol, Boswellia Serrata and vitamin D.

1. Nettle root extract (Urticaria Dioca) helps

• maintain a healthy balance of desirable prostaglandins,
• affects the proteins that carry sex hormones,  and
• may help balance hormone levels that affect prostate function. ^{http://www.ncbi.nlm.nih.gov/pubmed/18072824}

Prostaglandins: One of a number of hormone-like substances that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation. Prostaglandins are derived from a chemical called arachidonic acid.

2. Betasitosterol is the most active constituent of Pygeum africanum and has been used for decades as an effective natural therapy for BHP.  In 18 randomized controlled trials, the beneficial effects of Betasitosterol were reducing Nocturia (waking during the night to urinate) by 19% and residual urine volume by 24% while increasing peak urine flow by 23%. ^{http://www.ncbi.nlm.nih.gov/pubmed/11869585}

3. Boswellia Serrata is known for its anti-inflammatory properties, a common issue in prostate dysfunction. When used in combination with betastitosterol it has been shown to reduce inflammation in the prostate and surrounding tissue thereby alleviating the painful symptoms of BPH. 

4. Vitamin D3 deficiency has been linked in epidemiological studies to benign prostate hyperplasia (BPH).  Vitamin D’s relationship in calcium metabolism also plays a key role.  Therefore, delivering therapeutically-effective dosages in addition to the other active ingredients packs a punch against BPH. ^{http://www.ncbi.nlm.nih.gov/pubmed/24979517}

When taken together, this combination of phytonutrients results in an enhanced therapeutic effect for prostate health with none of the side effects of currently used pharmaceutical treatments.

Supplement Facts

Recommended Dosage: 1 per day or as directed by physician

Due to the nature of the product, suppositories cannot be returned or exchanged.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

WARNINGS:

• Although safe for children, this product should be kept out of the reach of children.
• Do not use if the suppositories are open or damaged.
• As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
• This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.                                                                                                                            

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.

References

Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review

Tommaso Castelli, et al

Int Braz J Urol. 2016 May-Jun; 42(3): 422–430

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920557/

BPH and prostate cancer risk

Indian J Urol 2014 Apr-Jun; 30(2): 214–218

Saiful Miah and James Catto

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989826/

Deficiency of vitamin D and elevated aldosterone in prostate hyperplasia

Adv Clin Exp Med 2014 May-Jun; 23(3):441-6

Yalçınkaya S, et al

http://www.ncbi.nlm.nih.gov/pubmed/24979517

Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats

Andrologia 2012 May; 44 Suppl 1:396-409

Nahata A¹, Dixit VK

http://www.ncbi.nlm.nih.gov/pubmed/21806658

Urtica dioica; Urtica urens (nettle). Monograph

Altern Med Rev 2007 Sep; 12(3):280-4

[No authors listed]

http://www.ncbi.nlm.nih.gov/pubmed/18072824

A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix

Phytomedicine 2007 Aug; 14(7-8):568-79

Chrubasik JE

http://www.ncbi.nlm.nih.gov/pubmed/17509841

Vitamin D–Related Genetic Variation, Plasma Vitamin D, and Risk of Lethal Prostate Cancer: A Prospective Nested Case–Control Study

J Natl Cancer Inst May 2, 2012; 104(9): 690–699

Irene M. Shui, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341310/

Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

Carcinogenesis May 2009; 30(5): 769–776

Jiyoung Ahn, et al

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675652/