Why Suppositories Make Sense

The mentioning of rectal suppositories often results in a brief silence followed by a surprised nervous laugh.  However, when the rationale of how rectal suppositories could be effective and make the difference between health and sickness, opinions quickly change from surprise to appreciation.

There is a growing acknowledgement of the need to provide safer, more cost-effective treatments that can either reduce the need for pharmaceuticals (ie: drugs) and/or to reduce their side effects. Currently, there exists ample research to demonstrate nutrients, herbals and nutraceuticals can do just that, if only they could be absorbed in such a manner as to allow greater therapeutic effect. Rectal suppositories clearly offer a safer and demonstrably more effective option.

In the U.S. there always has been a perceived patient compliance issue with the marketing of rectal suppositories. It has been assumed that although the rest of the world (especially the Japanese and Europeans) are comfortable with the use of suppositories, Americans would resist such a mode of delivery. However, in the ten years of selling the products, they have found the adage “some will and some won’t” to be true. Also, there is the American public’s predisposition to do or take whatever it takes, if it is effective.

How do Rectal Suppositories Work?

All drugs, or compounds that act like drugs, when administered orally, are absorbed from the gastrointestinal tract into the portal venous circulation and pass through the liver (first pass metabolism) where the process of drug metabolism begins. Suppositories, like intravenous (IV), intramuscular (IM), and transdermal methods of administration, bypass this “first pass” effect and are absorbed into the lower and middle hemorroidal veins without encountering liver metabolism. In addition, the rectum is filled with blood vessels that offer direct access into the body’s bloodstream via the inferior vena cava. This allows for rapid access to systemic circulation.

When nutrients are put into an active delivery system, called a suppository base, and then placed in the rectum, a “transfer” of water from the rectum to the fat-based suppository must occur for the separation of the active ingredients from the base into the rectal mucosa.  Zetpil™’s proprietary base is formulated with key ingredients that not only protect the active ingredients but also facilitate the movement of the active compounds from the base to the rectum.  This technology facilitates solubility, and allows a compound that is usually insoluble in water (hydrophobic) to dissolve, and thus be absorbed. This is crucial for poorly absorbed compounds.

Zetpil™ suppositories are comfortable, non-irritating, rapid-melting, fully absorbed in 15-20 minutes, and imperceptible after insertion.

Why Suppositories Make Sense

• Rectal suppositories deliver nutrients directly into the bloodstream, resulting in superior nutrition.
• The rectum is ideal for nutrient absorption because it is not buffered and has a neutral pH.  Unlike the stomach and intestines, there is no acid or enzymatic activity that causes degradation of the nutrients.
• The anorectal physiology provides a large surface area for nutrient absorption.
• The rectal mucosa is capable of tolerating a much higher level of irritation than gastric mucosa.
• Suppository formulations are extremely efficient in delivering medications because they do not occupy much volume.  Therefore, suppositories can deliver a higher concentration of vitamins, minerals, amino acids and nutraceuticals when compared to foods or oral supplements required to maintain health.
• Suppositories eliminate food interactions and competitive absorption chemistry which occurs with oral supplementation. This further increases nutrient bioavailability and thus, bioactivity.

The Zetpil “NOW” Solution

Comfortable, easy to use and cost effective.

Zetpil™ has developed a suppository that is comfortable, cost effective and easy to take.  They have developed an entire line of herbal, nutrient and nutraceutical rectal suppositories which demonstrate high levels of safety, tolerance, and efficacy that cannot be matched by most of the current nutrient formulations on the world’s market.  Zetpil™ is not only nutrition you can feel but represents the most honest nutritional product on the market today- period.

The Science to Support Rectal Suppositories

The following are the words of scientists and researchers around the world who explore this field of science and medicine.  We believe it helps the patient population understand the validity and therapeutic potential of this mode of delivery.